Akihiro Hirakawa Selected Research

Therapeutics

9/2023	Racial differences in longitudinal toxicities of anticancer agents in early phase cancer clinical trials.
3/2023	A phase II randomized trial of metastasis-directed therapy with alpha emitter radium-223 in men with oligometastatic castration-resistant prostate cancer (MEDAL).
1/2023	Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19.
7/2022	Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells.
1/2021	Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan.
12/2020	Use of unapproved or off-label drugs in Japan for the treatment of graft-versus-host disease and post-transplant viral infection.
8/2020	A phase 2 basket trial of combination therapy with trastuzumab and pertuzumab in patients with solid cancers harboring human epidermal growth factor receptor 2 amplification (JUPITER trial).
6/2020	BRCA1 promoter methylation in breast cancer patients is associated with response to olaparib/eribulin combination therapy.
1/2020	Response of intraductal carcinoma of the prostate to androgen deprivation therapy predicts prostate cancer prognosis in radical prostatectomy patients.
1/2020	Induced pluripotent stem cell-derived tenocyte-like cells promote the regeneration of injured tendons in mice.

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Akihiro Hirakawa Research Topics

Disease

24	Neoplasms (Cancer) 02/2024 - 01/2010
8	Prostatic Neoplasms (Prostate Cancer) 02/2024 - 01/2018
8	Osteoarthritis 12/2023 - 01/2017
8	Breast Neoplasms (Breast Cancer) 09/2022 - 01/2008
7	Neoplasm Metastasis (Metastasis) 02/2024 - 07/2012
7	X-Linked Bulbo-Spinal Atrophy 11/2022 - 01/2016
7	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2021 - 12/2013
5	Atrial Fibrillation 12/2023 - 11/2018
5	Adenocarcinoma 04/2023 - 01/2012
5	Disease Progression 01/2023 - 01/2018
4	COVID-19 12/2023 - 01/2021
4	Pain (Aches) 12/2023 - 02/2016
4	Stomach Neoplasms (Stomach Cancer) 11/2023 - 01/2012
4	Inflammation (Inflammations) 01/2023 - 11/2015
4	Infections 01/2023 - 07/2019
4	Hemorrhage 01/2021 - 05/2015
4	Noninfiltrating Intraductal Carcinoma (DCIS) 12/2020 - 02/2016
3	Stroke (Strokes) 12/2023 - 12/2018
3	Respiratory Syncytial Virus Infections 10/2023 - 07/2019
3	Parkinson Disease (Parkinson's Disease) 01/2023 - 01/2018
3	Stress Urinary Incontinence 10/2020 - 03/2014
3	Muscle Weakness 03/2018 - 12/2013
3	Brain Injuries (Brain Injury) 10/2017 - 11/2015
2	Tachycardia (Tachyarrhythmias) 12/2023 - 11/2022
2	Contracture 11/2023 - 09/2019
2	Neuromuscular Diseases (Neuromuscular Disease) 10/2023 - 01/2021
2	Osteomyelitis 09/2023 - 07/2019
2	Sarcoma (Soft Tissue Sarcoma) 01/2023 - 01/2018
2	Carcinosarcoma 01/2023 - 06/2016
2	Thrombosis (Thrombus) 01/2023 - 01/2021
2	Arthritis (Polyarthritis) 07/2022 - 08/2017
2	Heterotopic Ossification (Ectopic Ossification) 03/2022 - 09/2019
2	Coronary Artery Disease (Coronary Atherosclerosis) 01/2022 - 05/2015
2	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2021 - 04/2018
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 04/2014
2	Osteoporosis 07/2020 - 07/2020
2	Triple Negative Breast Neoplasms 06/2020 - 01/2019
2	Cognitive Dysfunction 01/2020 - 11/2018
2	Out-of-Hospital Cardiac Arrest 06/2019 - 09/2018
2	Body Weight (Weight, Body) 05/2019 - 06/2013
2	Granuloma 01/2019 - 01/2018
2	Hematoma 09/2018 - 08/2017
2	Carcinoma (Carcinomatosis) 05/2018 - 12/2011

Drug/Important Bio-Agent (IBA)

14	Biomarkers (Surrogate Marker)IBA 10/2023 - 10/2011
4	Paclitaxel (Taxol)FDA LinkGeneric 11/2023 - 02/2013
4	Cisplatin (Platino)FDA LinkGeneric 11/2023 - 01/2010
4	human ERBB2 proteinIBA 01/2023 - 01/2010
4	CreatinineIBA 10/2021 - 01/2016
4	Prostate-Specific Antigen (Semenogelase)IBA 01/2020 - 02/2016
3	AntigensIBA 11/2023 - 01/2012
3	Hormones (Hormone)IBA 12/2020 - 01/2010
2	Anti-Arrhythmia AgentsIBA 12/2023 - 11/2022
2	Immunosuppressive Agents (Immunosuppressants)IBA 12/2023 - 02/2021
2	LigandsIBA 11/2023 - 01/2023
2	CateninsIBA 11/2023 - 01/2017
2	Ointments (Pastes)IBA 11/2023 - 01/2018
2	NivolumabIBA 10/2023 - 01/2018
2	Palivizumab FDA Link 10/2023 - 01/2021
2	Anti-Bacterial Agents (Antibiotics)IBA 09/2023 - 07/2019
2	CytokinesIBA 01/2023 - 02/2016
2	ErbB Receptors (EGF Receptor)IBA 01/2023 - 04/2014
2	Glycoproteins (Glycoprotein)IBA 01/2023 - 01/2023
2	Mexiletine (Mexitil)FDA LinkGeneric 11/2022 - 11/2018
2	Etoposide (VP 16)FDA LinkGeneric 03/2021 - 01/2010
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 03/2021 - 07/2012
2	Trastuzumab (Herceptin)FDA Link 08/2020 - 03/2010
2	alfacalcidolIBA 07/2020 - 07/2020
2	GlucocorticoidsIBA 07/2020 - 07/2020
2	olaparibIBA 06/2020 - 01/2019
2	eribulin FDA Link 06/2020 - 01/2019
2	Hemoglobins (Hemoglobin)IBA 05/2020 - 02/2016
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020 - 07/2019
2	AndrogensIBA 01/2020 - 12/2017
2	Acetates (Acetic Acid Esters)FDA Link 05/2019 - 12/2017
2	Leuprolide (Lupron)FDA LinkGeneric 05/2019 - 12/2017
2	Tumor Biomarkers (Tumor Markers)IBA 05/2019 - 01/2012
2	SteroidsIBA 01/2019 - 01/2018
2	Silver NitrateIBA 01/2019 - 01/2018
2	AnticoagulantsIBA 11/2018 - 08/2017
2	CreatineIBA 03/2018 - 01/2016

Therapy/Procedure

24	Therapeutics 09/2023 - 01/2012
8	Prostatectomy (Retropubic Prostatectomy) 02/2024 - 09/2017
8	Drug Therapy (Chemotherapy) 11/2023 - 01/2010
4	Arthrodesis 12/2023 - 07/2019
4	Arthroplasty 07/2023 - 04/2020
4	Transplantation 07/2022 - 04/2018
3	Castration 02/2024 - 12/2020
3	Operative Surgical Procedures 12/2023 - 03/2023
3	Radiotherapy 03/2023 - 04/2016
3	Catheter Ablation 11/2022 - 01/2021
3	Chemoradiotherapy 05/2019 - 01/2017
3	Adjuvant Chemotherapy 01/2018 - 03/2010
2	Lymph Node Excision (Lymph Node Dissection) 09/2022 - 06/2016
2	Reoperation 03/2022 - 09/2019
2	Cesarean Section (Caesarean Section) 08/2019 - 01/2017
2	Debridement 07/2019 - 04/2010
2	Cardiopulmonary Resuscitation (CPR) 06/2019 - 09/2018
2	Time-to-Treatment 05/2019 - 01/2012
2	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 12/2018 - 05/2015
2	Activities of Daily Living (ADL) 03/2018 - 12/2013